Thiele K, Jahn U, Geissmann F, Zirngibl L
Arzneimittelforschung. 1984;34(1):1-4.
Within the course of the research project for finding new cardiovascular drugs we have synthetized since 1976 piperazine- and piperidine derivatives of theophylline. The screening shows for the substances Sgd 19578 (flufylline) and Sgd 14480 (fluprofylline) a long-lasting blood pressure lowering activity as well as a remarkable serotonin- and histamine antagonism and broncholytic activity. On the basis of these results these compounds were selected for further investigation.
在寻找新型心血管药物的研究项目过程中，自1976年以来我们合成了茶碱的哌嗪和哌啶衍生物。筛选结果表明，化合物Sgd 19578（多索茶碱）和Sgd 14480（二羟丙茶碱）具有持久的降压活性以及显著的5-羟色胺和组胺拮抗作用及支气管溶解活性。基于这些结果，选择这些化合物作进一步研究。
