GTP结合蛋白一级结构中的同源性：EF-Tu和p21的核苷酸结合位点
Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21.
作者信息
Leberman R, Egner U
出版信息
EMBO J. 1984 Feb;3(2):339-41. doi: 10.1002/j.1460-2075.1984.tb01808.x.
Abstract
An examination of the available amino acid sequences of GTP-binding proteins has revealed that each contains a polypeptide essentially homologous for all of them. These sequences for elongation factor-Tu (EF-Tu) and the human bladder protein p21 exhibit a singular degree of homology (50%). Chemical and structural evidence indicates that this sequence in EF-Tu constitutes part of the nucleotide-binding site. The homologous sequences may therefore contribute to the GTP-binding sites of the other proteins.
摘要
对GTP结合蛋白的现有氨基酸序列进行检查后发现，每种蛋白都含有一段对所有这些蛋白而言基本同源的多肽。延伸因子-Tu（EF-Tu）和人膀胱蛋白p21的这些序列表现出独特程度的同源性（50%）。化学和结构证据表明，EF-Tu中的这一序列构成了核苷酸结合位点的一部分。因此，这些同源序列可能对其他蛋白的GTP结合位点有贡献。
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