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T24人膀胱癌癌基因的核苷酸序列分析

Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene.

作者信息

Reddy E P

出版信息

Science. 1983 Jun 3;220(4601):1061-3. doi: 10.1126/science.6844927.

DOI:10.1126/science.6844927
PMID:6844927
Abstract

The nucleotide sequence of the T24 human bladder carcinoma oncogene was determined, and the coding and noncoding sequences of the genome were identified. The amino acid sequence of p21, the translational product of the T24 oncogene, was predicted from the nucleotide sequence of the oncogene. Comparison of this sequence with that of the normal cellular homolog showed that a single point mutation in the coding sequences of the T24 oncogene resulted in the acquisition of transforming properties. Other differences between the T24 oncogene and its normal cellular homolog were found in the 5' noncoding and 3' noncoding sequences, but these differences appear to be due to polymorphism and do not play a significant role in the transformation process.

摘要

测定了T24人膀胱癌癌基因的核苷酸序列，并鉴定了基因组的编码和非编码序列。根据该癌基因的核苷酸序列预测了T24癌基因翻译产物p21的氨基酸序列。将该序列与正常细胞同源物的序列进行比较，结果表明T24癌基因编码序列中的单个点突变导致了转化特性的获得。在T24癌基因及其正常细胞同源物之间的5'非编码和3'非编码序列中发现了其他差异，但这些差异似乎是由于多态性引起的，在转化过程中不发挥重要作用。

相似文献

1
Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene.T24人膀胱癌癌基因的核苷酸序列分析
Science. 1983 Jun 3;220(4601):1061-3. doi: 10.1126/science.6844927.
2
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene.一个点突变导致了T24人膀胱癌癌基因获得转化特性。
Nature. 1982 Nov 11;300(5888):149-52. doi: 10.1038/300149a0.
3
Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.T24膀胱癌转化基因的激活与单个氨基酸变化有关。
Nature. 1982 Dec 23;300(5894):762-5. doi: 10.1038/300762a0.
4
Characterization of a human transforming gene isolated from T24 bladder carcinoma cells.从T24膀胱癌细胞中分离出的一种人类转化基因的特性分析。
Fed Proc. 1984 May 15;43(8):2280-6.
5
Spontaneous activation of a human proto-oncogene.人类原癌基因的自发激活。
Proc Natl Acad Sci U S A. 1983 Aug;80(15):4679-83. doi: 10.1073/pnas.80.15.4679.
6
Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue.T24人膀胱癌癌基因及其正常同源基因的完整核苷酸序列。
Nature. 1983 Mar 3;302(5903):33-7. doi: 10.1038/302033a0.
7
Prediction of the three-dimensional structure of the transforming region of the EJ/T24 human bladder oncogene product and its normal cellular homologue.人EJ/T24膀胱癌基因产物及其正常细胞同源物转化区三维结构的预测
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5253-7. doi: 10.1073/pnas.80.17.5253.
8
Predicted nucleotide-binding properties of p21 protein and its cancer-associated variant.p21蛋白及其癌症相关变体的预测核苷酸结合特性。
Nature. 1983 Apr 28;302(5911):842-4. doi: 10.1038/302842a0.
9
Human EJ bladder carcinoma oncogene is homologue of Harvey sarcoma virus ras gene.人EJ膀胱癌细胞癌基因是哈维肉瘤病毒ras基因的同源物。
Nature. 1982 Jun 10;297(5866):474-8. doi: 10.1038/297474a0.
10
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.c-bas/has人类原癌基因内的替代点突变导致转化特性的获得。
Nature. 1983 Jun 30;303(5920):775-9. doi: 10.1038/303775a0.

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RNA. 2001 Feb;7(2):314-27. doi: 10.1017/s1355838201001698.
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A splicing enhancer in the 3'-terminal c-H-ras exon influences mRNA abundance and transforming activity.3'-末端c-H-ras外显子中的一个剪接增强子影响mRNA丰度和转化活性。
J Virol. 1997 Sep;71(9):6416-26. doi: 10.1128/JVI.71.9.6416-6426.1997.
5
Apoptosis of human BEL-7402 hepatocellular carcinoma cells released by antisense H-ras DNA--in vitro and in vivo studies.反义H-ras DNA诱导人BEL-7402肝癌细胞凋亡的体内外研究
J Cancer Res Clin Oncol. 1997;123(1):25-33. doi: 10.1007/BF01212611.
6
Suppression of albumin enhancer activity by H-ras and AP-1 in hepatocyte cell lines.H-ras和AP-1对肝细胞系中白蛋白增强子活性的抑制作用。
Mol Cell Biol. 1994 Mar;14(3):1531-43. doi: 10.1128/mcb.14.3.1531-1543.1994.
7
Assessment of DNA damage and repair in specific genomic regions by quantitative immuno-coupled PCR.通过定量免疫偶联PCR评估特定基因组区域的DNA损伤与修复
Nucleic Acids Res. 1994 Jun 25;22(12):2351-9. doi: 10.1093/nar/22.12.2351.
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Homologies in the primary structure of GTP-binding proteins: the nucleotide-binding site of EF-Tu and p21.GTP结合蛋白一级结构中的同源性：EF-Tu和p21的核苷酸结合位点
EMBO J. 1984 Feb;3(2):339-41. doi: 10.1002/j.1460-2075.1984.tb01808.x.
9
Human oncogenes.人类癌基因。
Hum Genet. 1984;66(2-3):132-42. doi: 10.1007/BF00286587.
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Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.哈维鼠肉瘤病毒p21 ras蛋白：最靠近羧基末端的半胱氨酸的生物学和生化意义
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