Corsellis J A, Janota I, Marshall A K
Neuropathol Appl Neurobiol. 1983 Jul-Aug;9(4):261-70. doi: 10.1111/j.1365-2990.1983.tb00113.x.
The neuropathological aspects of vaccination against pertussis have been analysed. This has been done partly by considering the previous literature and partly by searching for data on any child whose death since 1960 has been thought to have a possible relationship to the vaccination. Twenty-nine in due course were identified on whom a post-mortem examination had been made. Eighteen had died within 3 weeks of inoculation - the remaining eleven had survived the initial illness but had remained retarded, epileptic and disabled. Although a variety of cerebral abnormalities were found, neither those recorded in the present study nor those abstracted from previous case reports, have demonstrated a recurring pattern of inflammatory or other damage which could be accepted as a specific reaction to immunization against whooping cough. Those reactive changes that were occasionally found appear to be indistinguishable from those seen in many other infantile encephalopathies occurring as the result of a hypoxic/ischaemic state supervening on a complex of respiratory complications, fever and convulsions.
已对百日咳疫苗接种的神经病理学方面进行了分析。部分是通过参考以往文献，部分是通过查找自1960年以来任何被认为可能与疫苗接种有关的儿童死亡数据来进行分析的。最终确定了29例进行了尸检的病例。18例在接种后3周内死亡，其余11例在最初疾病中存活下来，但仍有智力发育迟缓、癫痫和残疾问题。尽管发现了多种脑部异常情况，但无论是本研究记录的异常情况，还是从以往病例报告中提取的异常情况，均未显示出可被视为针对百日咳免疫的特异性反应的反复出现的炎症或其他损伤模式。偶尔发现的那些反应性变化似乎与许多其他因缺氧/缺血状态叠加在呼吸并发症、发热和惊厥复合体上而发生的婴儿脑病中所见的变化并无区别。
