Caspary D M, Havey D C, Faingold C L
Exp Neurol. 1983 Nov;82(2):491-8. doi: 10.1016/0014-4886(83)90419-3.
Iontophoretic application of acetylcholine (ACh) onto neurons in the dorsal cochlear nucleus (DCN) resulted in an inhibition of the tone-evoked responses of 85% of neurons which were affected. That effect in the DCN contrasts with the predominance of excitatory effects of ACh seen in ventral cochlear nucleus (VCN) neurons. The ACh-induced inhibition in the DCN had a considerably slower onset and time course of recovery than that seen with glycine-induced inhibition. The degree of ACh effects was constant with increasing intensity or attained a maximum effect at 20 to 30 dB above best-frequency threshold in contrast to glycine, which had effects that were relatively greater at low intensities. These findings suggested a modulatory role for ACh at DCN and VCN synapses.
将乙酰胆碱（ACh）经离子电渗法作用于蜗背侧核（DCN）的神经元，导致85%受影响神经元的音调诱发反应受到抑制。DCN中的这种效应与在蜗腹侧核（VCN）神经元中观察到的ACh兴奋性效应占主导形成对比。DCN中ACh诱导的抑制起效和恢复时间进程比甘氨酸诱导的抑制要慢得多。与甘氨酸在低强度时效应相对较大不同，ACh效应的程度随强度增加而恒定，或在高于最佳频率阈值20至30分贝时达到最大效应。这些发现提示ACh在DCN和VCN突触中起调节作用。
