马血清酯酶（Es）和线粒体谷氨酸草酰乙酸转氨酶（GOTM）基因座的连锁。马与小鼠的同源性。

Linkage of the equine serum esterase (Es) and mitochondrial glutamate oxaloacetate transaminase (GOTM) loci. A horse-mouse homology.

作者信息

Andersson L, Sandberg K, Adalsteinsson S, Gunnarsson E

出版信息

J Hered. 1983 Sep-Oct;74(5):361-4. doi: 10.1093/oxfordjournals.jhered.a109811.

DOI:10.1093/oxfordjournals.jhered.a109811

Abstract

Three previously described electrophoretic phenotypes of mitochondrial glutamate oxaloacetate transaminase (GOTM) in horse leukocytes are shown to be controlled by two codominant alleles at a single autosomal locus. The GOTM locus is linked to the serum esterase locus (Es), as no recombination between these loci was observed among 16 informative offspring in one sire family. The results assign GOTM to equine linkage group (LG) II. The hypothesis that a part of LG II (e-Es) shares homologies with mouse chromosome 8 is thus confirmed, as the murine homologue of GOTM is located within the cluster of esterase loci on chromosome 8. The assumed homology also involves rabbit LG VI, rat LG V, and human chromosome 16. The observation is a striking example of the conservation of linkage relationships between mammalian species.

摘要

马白细胞中线粒体谷氨酸草酰乙酸转氨酶（GOTM）先前描述的三种电泳表型显示由一个常染色体位点上的两个共显性等位基因控制。GOTM位点与血清酯酶位点（Es）连锁，因为在一个父系家族的16个信息丰富的后代中未观察到这些位点之间的重组。结果将GOTM定位到马连锁群（LG）II。因此证实了LG II的一部分（e-Es）与小鼠8号染色体具有同源性的假设，因为GOTM的小鼠同源物位于8号染色体上的酯酶基因座簇内。假定的同源性还涉及兔LG VI、大鼠LG V和人类16号染色体。这一观察结果是哺乳动物物种间连锁关系保守性的一个显著例子。