Gruber C A, Gilbertson T J
Prostaglandins. 1978 Mar;15(3):429-36. doi: 10.1016/0090-6980(78)90126-0.
Prostaglandin E2 (PGE2)-induced discocyte leads to echinocytic transformation has no effect on the viscosity or osmotic fragility of normal or sickle cell erythrocytes. Membrane permeability, reflected as potassium efflux, is significantly affected in normal erythrocytes when greater than 90% of the cells are morphologically transformed to the echinocytic III stage (PGE2 concentration of 1--2x10(6) ng/ml blood). This potassium loss is significant in sickle erythrocytes when 50-70% of the cell population has been transformed (PGE2 concentration, 5x10(5) ng/ml blood). This change in membrane permeability represents one-half to one-third the flux that occurs with sickling (i.e., greater than 80% of the erythrocytes sickled).
前列腺素E2（PGE2）诱导的盘状细胞向棘状细胞转化对正常或镰状细胞红细胞的粘度或渗透脆性没有影响。当超过90%的细胞在形态上转化为棘状细胞III期（PGE2浓度为1--2x10(6) ng/ml血液）时，以钾外流反映的膜通透性在正常红细胞中受到显著影响。当50-70%的细胞群体发生转化时（PGE2浓度为5x10(5) ng/ml血液），镰状红细胞中的这种钾流失是显著的。这种膜通透性的变化代表了镰状化时发生的通量的二分之一到三分之一（即超过80%的红细胞发生镰状化）。
