Clouse R E, Lustman P J
N Engl J Med. 1983 Dec 1;309(22):1337-42. doi: 10.1056/NEJM198312013092201.
Over a six-month period 50 patients referred for clinical esophageal manometry were independently evaluated for psychiatric diagnoses to determine whether there was any association between psychiatric illness and esophageal motility disorders. The manometric studies were blindly classified according to findings in the esophageal body. Twenty-five patients were classified as having one or more of the following contraction abnormalities: an increase in mean wave amplitude, an increase in mean wave duration, an increased frequency of abnormal motor responses, or the presence of triple-peaked waves. Psychiatric diagnoses were made in 21 (84 per cent) of the 25 patients but in only 4 (31 per cent) of the 13 patients with normal manometric patterns (P less than 0.005) and 4 (33 per cent) of the 12 with other manometric abnormalities (P less than 0.01). The fact that psychiatric illness is associated with a specific cluster of esophageal contraction abnormalities may provide a basis for further investigation of the relation between emotional disturbances and disorders of gastrointestinal motility.
在六个月的时间里，对50名因临床食管测压而转诊的患者进行了独立的精神疾病诊断评估，以确定精神疾病与食管动力障碍之间是否存在关联。根据食管体部的检查结果，对测压研究进行了盲法分类。25名患者被归类为有以下一种或多种收缩异常：平均波幅增加、平均波持续时间增加、异常运动反应频率增加或出现三峰波。25名患者中有21名（84%）被诊断出患有精神疾病，而在13名测压模式正常的患者中只有4名（31%）被诊断出患有精神疾病（P<0.005），在12名有其他测压异常的患者中有4名（33%）被诊断出患有精神疾病（P<0.01）。精神疾病与特定的食管收缩异常群相关这一事实，可能为进一步研究情绪障碍与胃肠动力障碍之间的关系提供依据。
