贲门失弛缓症临床特征的性别差异：一项前瞻性研究。
Gender effect on clinical features of achalasia: a prospective study.
作者信息
Mikaeli Javad, Farrokhi Farnoosh, Bishehsari Faraz, Mahdavinia Mahboobeh, Malekzadeh Reza
机构信息
Achalasia Research Unit, Digestive Disease Research Center, Tehran University of Medical Sciences, Shariati Hospital, Tehran 14114, Iran.
出版信息
BMC Gastroenterol. 2006 Apr 1;6:12. doi: 10.1186/1471-230X-6-12.
BACKGROUND
Achalasia is a well-characterized esophageal motor disorder but the rarity of the disease limits performing large studies on its demographic and clinical features.
METHODS
Prospectively, 213 achalasia patients (110 men and 103 women) were enrolled in the study. The diagnosis established by clinical, radiographic, and endoscopic as well as manometry criteria. All patients underwent a pre-designed clinical evaluation before and within 6 months after the treatment.
RESULTS
Solid dysphagia was the most common clinical symptom in men and women. Chest pain was the only symptom which was significantly different between two groups and was more complained by women than men (70.9% vs. 54.5% P value = 0.03). Although the occurrence of chest pain significantly reduced after treatment in both groups (P < 0.001), it was still higher among women (32% vs. 20.9% P value = 0.04). In both sexes, chest pain did not relate to the symptom duration, LES pressure and type of treatment patients received. Also no significant relation was found between chest pain and other symptoms expressed by men and women before and after treatment. Chest pain was less frequently reported by patients over 56 yrs of age in comparison to those less than 56 yrs (p < 0.05).
CONCLUSION
It seems that chest pain is the distinct symptom of achalasia which is affected by sex as well as age and does not relate to the duration of illness, LESP and the type of treatment achalasia patients receive.
背景
贲门失弛缓症是一种特征明确的食管运动障碍性疾病，但该疾病的罕见性限制了对其人口统计学和临床特征进行大规模研究。
方法
前瞻性地纳入了213例贲门失弛缓症患者（110例男性和103例女性）。通过临床、影像学、内镜以及测压标准确立诊断。所有患者在治疗前及治疗后6个月内均接受了预先设计的临床评估。
结果
固体食物吞咽困难是男性和女性最常见的临床症状。胸痛是两组之间唯一有显著差异的症状，女性比男性更常抱怨胸痛（70.9%对54.5%，P值=0.03）。尽管两组治疗后胸痛的发生率均显著降低（P<0.001），但女性的发生率仍较高（32%对20.9%，P值=0.04）。在男性和女性中，胸痛均与症状持续时间、LES压力以及患者接受的治疗类型无关。治疗前后，胸痛与男性和女性表达的其他症状之间也未发现显著相关性。与年龄小于56岁的患者相比，年龄超过56岁的患者较少报告胸痛（p<0.05）。
结论
胸痛似乎是贲门失弛缓症的独特症状，受性别和年龄影响，与疾病持续时间、LES压力以及贲门失弛缓症患者接受的治疗类型无关。
Zotero 插件