Adami H O, Hansen J, Jung B, Rimsten A
Br J Cancer. 1980 Jul;42(1):71-7. doi: 10.1038/bjc.1980.204.
1330 consecutively diagnosed breast-cancer patients, and an equal number of paired aged-matched controls without breast cancer, were investigated for a familial history of breast cancer. Patients and controls received identical questionnaires. One relative or more with breast cancer was reported by 18.6% of the patients and by 12.3% of the controls, giving a standardized relative risk (SRR) of 1.6 (P < 0.01). One or more first-degree relatives with breast cancer were reported by 11.2% of the patients and by 6.8% of the controls, with an SRR of 1.7 (P < 0.01). For second-degree relatives the SRR was 1.5 (P < 0.05). Of the patients, 3.9% had mothers with breast cancer compared to 2.7% of the controls (SRR = 1.4, N.S.). One or more sisters with breast canceer were reported by 10.1% of the patients and by 5.1% of the controls (SRR = 2.0, P < 0.01). No distinct difference in familiality between the different age groups was found.
对1330例连续确诊的乳腺癌患者以及数量相等的年龄匹配的非乳腺癌对照者进行了乳腺癌家族史调查。患者和对照者填写相同的问卷。18.6%的患者报告有一名或多名患乳腺癌的亲属，对照者中这一比例为12.3%，标准化相对风险（SRR）为1.6（P<0.01）。11.2%的患者报告有一名或多名患乳腺癌的一级亲属，对照者中这一比例为6.8%，SRR为1.7（P<0.01）。二级亲属的SRR为1.5（P<0.05）。患者中3.9%的母亲患有乳腺癌，对照者中这一比例为2.7%（SRR=1.4，无统计学意义）。10.1%的患者报告有一名或多名患乳腺癌的姐妹，对照者中这一比例为5.1%（SRR=2.0，P<0.01）。不同年龄组之间在家族聚集性方面未发现明显差异。
