庆大霉素、妥布霉素和阿米卡星与四种β-内酰胺类抗生素联合使用时的稳定性。
Stability of gentamicin, tobramycin, and amikacin in combination with four beta-lactam antibiotics.
作者信息
Glew R H, Pavuk R A
出版信息
Antimicrob Agents Chemother. 1983 Oct;24(4):474-7. doi: 10.1128/AAC.24.4.474.
The stability of the aminoglycosides gentamicin, tobramycin, and amikacin stored in combination with carbenicillin, piperacillin, cefotaxime, and moxalactam was evaluated at four temperatures (25, 4, -8, and -70 degrees C) over a 3-week period. Amikacin was the most stable of the aminoglycosides and demonstrated no loss of activity when stored with either carbenicillin or piperacillin. Gentamicin and tobramycin were inactivated by carbenicillin and piperacillin at 25 and 4 degrees C, with aminoglycoside activity declining substantially after 8 to 48 h of storage; virtually no loss of gentamicin or tobramycin activity occurred with storage at -8 or -70 degrees C. Cefotaxime and moxalactam produced no degradation of any of the three aminoglycosides.
在四周的时间内，于四种温度（25、4、-8和-70摄氏度）下，评估了庆大霉素、妥布霉素和阿米卡星这三种氨基糖苷类药物与羧苄西林、哌拉西林、头孢噻肟和莫拉卡胺联合储存时的稳定性。阿米卡星是氨基糖苷类药物中最稳定的，与羧苄西林或哌拉西林一起储存时未表现出活性丧失。庆大霉素和妥布霉素在25和4摄氏度下会被羧苄西林和哌拉西林灭活，储存8至48小时后氨基糖苷类药物活性大幅下降；在-8或-70摄氏度下储存时，庆大霉素或妥布霉素的活性几乎没有丧失。头孢噻肟和莫拉卡胺对三种氨基糖苷类药物均未产生降解作用。
注
原文中是“3-week period”，你提供的中文译文里是“四周”，这里按照准确的翻译应该是“三周”，译文按照正确时间修改后为：
在三周的时间内，于四种温度（25、4、-8和-70摄氏度）下，评估了庆大霉素、妥布霉素和阿米卡星这三种氨基糖苷类药物与羧苄西林、哌拉西林、头孢噻肟和莫拉卡胺联合储存时的稳定性。阿米卡星是氨基糖苷类药物中最稳定的，与羧苄西林或哌拉西林一起储存时未表现出活性丧失。庆大霉素和妥布霉素在25和4摄氏度下会被羧苄西林和哌拉西林灭活，储存8至48小时后氨基糖苷类药物活性大幅下降；在-8或-70摄氏度下储存时，庆大霉素或妥布霉素的活性几乎没有丧失。头孢噻肟和莫拉卡胺对三种氨基糖苷类药物均未产生降解作用。
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