Halperin J L, Cohen R A, Coffman J D
Cardiovasc Res. 1983 Nov;17(11):671-7. doi: 10.1093/cvr/17.11.671.
Fingertip blood flow was measured by venous occlusion plethysmography before and during a stressful mental task consisting of rapid serial arithmetic calculations in a 25 degrees C room. Significant rises in heart rate and blood pressure indicated that stress was actually induced in all individuals. During mental stress in normal subjects, blood flow decreased (46.4 +/- 6.2 to 22.4 +/- 4.9 ml X min-1 per 100 ml tissue; P less than 0.01) and vascular resistance increased (2.1 +/- 0.4 to 7.6 +/- 2.2 units; P less than 0.01). Patients with Raynaud's disease unexpectedly increased blood flow (15.4 +/- 4.2 to 21.6 +/- 5.7; P = 0.05) and decreased vascular resistance (9.7 +/- 2.3 to 7.1 +/- 1.4; P = 0.05). Ten additional normal subjects were studied in a cool room (20 degrees C). Their digits remained vasoconstricted during stress, as blood flow (7.4 +/- 2.9 to 5.1 +/- 1.3) and vascular resistance (31.5 +/- 11.1 to 34.4 +/- 8.2) varied insignificantly (P greater than 0.10). The digital vasodilatation which occurs during mental stress in patients with Raynaud's disease was not altered by pretreatment with oral indomethacin, with intra-arterial propranolol or atropine, or by digital nerve block. These findings suggest the existence of an active digital vasodilatory mechanism in patients with Raynaud's disease.
在25摄氏度的房间里，通过静脉阻塞体积描记法在一项紧张的心理任务（包括快速连续算术计算）之前和期间测量指尖血流量。心率和血压显著升高表明所有个体都实际感受到了压力。在正常受试者的心理压力期间，血流量减少（从46.4±6.2降至22.4±4.9 ml·min⁻¹/100 ml组织；P<0.01），血管阻力增加（从2.1±0.4增至7.6±2.2单位；P<0.01）。雷诺病患者出人意料地血流量增加（从15.4±4.2增至21.6±5.7；P = 0.05），血管阻力降低（从9.7±2.3降至7.1±1.4；P = 0.05）。另外10名正常受试者在凉爽的房间（20摄氏度）中接受研究。在压力期间，他们的手指保持血管收缩状态，因为血流量（从7.4±2.9降至5.1±1.3）和血管阻力（从31.5±11.1增至34.4±8.2）变化不显著（P>0.10）。雷诺病患者在心理压力期间出现的手指血管舒张不受口服消炎痛、动脉内注射心得安或阿托品预处理，或手指神经阻滞的影响。这些发现提示雷诺病患者存在一种活跃的手指血管舒张机制。
