Solinger A M, Adams L E, Friedman-Kien A E, Hess E V
Department of Internal Medicine, University of Cincinnati College of Medicine, Ohio 45267.
J Clin Immunol. 1988 Jan;8(1):32-42. doi: 10.1007/BF00915154.
Loss of normal immune homeostasis occurs in acquired immune deficiency syndrome (AIDS). We evaluated patients at the University of Cincinnati and New York University Medical Centers for serologic evidence of autoimmune changes. Specifically, tests for antinuclear and organ-specific antibodies by immunofluorescence, antisperm and anti-seminal plasma antibodies, rheumatoid factor by latex and sensitized sheep cell agglutination techniques, anti-polyadenosine (poly A), and single-stranded DNA antibodies were performed in human immunodeficiency virus (HIV) antibody-positive sera. A parallel study of mitogen responsiveness was performed and showed inhibition of response by AIDS and AIDS-related complex (ARC) sera. In spite of evidence of polyclonal B-cell activation, hyperglobulinemia, and the presence of antibodies to many infectious agents, as well as the known cellular immune abnormalities, the patients tested had a striking absence of these autoantibodies. The only major difference noted from normal controls, was a low but significant level of antibody binding to poly A. The autoimmune connective tissue diseases were not observed in this group of patients.
获得性免疫缺陷综合征（艾滋病）会出现正常免疫稳态的丧失。我们在辛辛那提大学和纽约大学医学中心对患者进行了评估，以寻找自身免疫变化的血清学证据。具体而言，采用免疫荧光法检测抗核抗体和器官特异性抗体、抗精子和抗精浆抗体，采用乳胶凝集试验和致敏绵羊细胞凝集技术检测类风湿因子，检测人类免疫缺陷病毒（HIV）抗体阳性血清中的抗多聚腺苷酸（多聚A）和单链DNA抗体。同时进行了一项关于丝裂原反应性的平行研究，结果显示艾滋病患者血清和艾滋病相关综合征（ARC）血清会抑制反应。尽管有证据表明存在多克隆B细胞活化、高球蛋白血症以及存在针对多种感染因子的抗体，还有已知的细胞免疫异常，但检测的患者中这些自身抗体却明显缺乏。与正常对照组相比，唯一的主要差异是与多聚A结合的抗体水平较低但具有统计学意义。该组患者未观察到自身免疫性结缔组织疾病。
