Beuche W, Wickboldt J, Friede R L
Clin Neuropathol. 1983;2(4):163-70.
Clinical, necropsy, and electron microscope findings are described for a patient with Lhermitte-Duclos disease. Evidence that the disease originated from granule cell precursors was obtained from electron microscopy and from reconstruction in step serial sections of microscopic lesions found in the contralateral cerebellar hemisphere. The latter indicate a process of proliferation and hypertrophy of granule cells at their site of origin in the superficial granular layer, along their normal path of migration, or else at their destination in the cerebellar granular layer.
本文描述了一例Lhermitte-Duclos病患者的临床、尸检及电子显微镜检查结果。电子显微镜检查以及对侧小脑半球微观病变连续切片重建结果均表明，该病起源于颗粒细胞前体。后者显示出颗粒细胞在其起源部位（浅表颗粒层）、沿正常迁移路径或在小脑颗粒层的最终位置出现增殖和肥大的过程。
