Lhermitte-Duclos disease--its minimal lesions in electron microscope data and CT findings.

Clinical, necropsy, and electron microscope findings are described for a patient with Lhermitte-Duclos disease. Evidence that the disease originated from granule cell precursors was obtained from electron microscopy and from reconstruction in step serial sections of microscopic lesions found in the contralateral cerebellar hemisphere. The latter indicate a process of proliferation and hypertrophy of granule cells at their site of origin in the superficial granular layer, along their normal path of migration, or else at their destination in the cerebellar granular layer.