Dawson E B, Frey M J, Moore T D, McGanity W J
Am J Clin Nutr. 1978 Jul;31(7):1188-97. doi: 10.1093/ajcn/31.7.1188.
The annual mortality rates for 1968 of six types of cardiovascular diseases among those persons over 45 years of age in 24 Texas communities were compared with respective community drinking water and urine metal levels of calcium, magnesium, potassium, lithium, strontium, and silicon. Numerous inverse correlations were found between mortality rates and the levels of various metals in both drinking water and urine. Positive correlations were also observed between several of the mortality rates and the ratio of the concentration of sodium to that of the other metals in both water and urine. Mean community urinary levels of lithium, magnesium, strontium, and silicon showed a direct correlation to the levels of exposure via the drinking water. The results of this study suggest that calcium, magnesium, lithium strontium, and silicon may protect against cardiovascular mortality; possibly, by competing with sodium and potassium for transport in the intestinal lumen, increasing excretion of sodium, or other mechanism.
将德克萨斯州24个社区中45岁以上人群1968年六种心血管疾病的年死亡率，与相应社区饮用水和尿液中钙、镁、钾、锂、锶和硅的金属含量进行了比较。在死亡率与饮用水和尿液中各种金属含量之间发现了许多负相关关系。在几种死亡率与水和尿液中钠浓度与其他金属浓度的比率之间也观察到正相关关系。社区锂、镁、锶和硅的平均尿液水平与通过饮用水的接触水平呈直接相关。这项研究的结果表明，钙、镁、锂、锶和硅可能预防心血管疾病死亡；可能是通过在肠腔中与钠和钾竞争运输、增加钠的排泄或其他机制来实现的。
