Berlyne G M, Adler A J, Ferran N, Bennett S, Holt J
Nephron. 1986;43(1):5-9. doi: 10.1159/000183709.
Renal silicon handling was investigated in 23 healthy adults using electrothermal atomic absorption techniques. The mean urinary silicon excretion was 33.1 +/- 3.85 mg/day; the mean renal silicon clearance was 88.6 +/- 7.94 ml/min; the mean fractional excretion of silicon was 86.35 +/- 8.1%, and the mean urine silicon concentration was 0.265 micrograms/ml. Using multiple correlation analysis, the urinary silicon was found to be highly significantly correlated with the urine magnesium concentration (p less than 0.001) and also with urinary sodium and urinary osmolality (p less than 0.01). 24-hour urinary silicon excretion was highly significantly correlated with fractional excretion of silicon (p less than 0.001), sodium (p less than 0.001), phosphorus (p less than 0.001), magnesium (p less than 0.001), and osmolar load. In split urine studies in 7 subjects urinary silicon was correlated highly significantly with urinary magnesium in all 7 and with urinary osmolality, urine calcium, and urine creatine concentration in 6 of 7. There was a highly significant correlation between renal silicon clearance and fractional excretion of silicon (p less than 0.0005), with magnesium excretion (p less than 0.01), and with sodium excretion. It is suggested that ion pairing of orthosilicate and magnesium may explain some of these urinary findings.
采用电热原子吸收技术对23名健康成年人的肾脏硅处理情况进行了研究。尿硅平均排泄量为33.1±3.85毫克/天；肾脏硅清除率平均为88.6±7.94毫升/分钟；硅的平均排泄分数为86.35±8.1%，尿硅浓度平均为0.265微克/毫升。通过多元相关分析发现，尿硅与尿镁浓度（p<0.001）、尿钠和尿渗透压（p<0.01）高度显著相关。24小时尿硅排泄量与硅的排泄分数（p<0.001）、钠（p<0.001）、磷（p<0.001）、镁（p<0.001）和渗透压负荷高度显著相关。在对7名受试者的分段尿液研究中，7名受试者的尿硅与尿镁均高度显著相关，7名中有6名的尿硅与尿渗透压、尿钙和尿肌酸浓度高度显著相关。肾脏硅清除率与硅的排泄分数（p<0.0005）、镁排泄量（p<0.01）和钠排泄量之间存在高度显著的相关性。有人提出，原硅酸与镁的离子配对可能解释了这些尿液检测结果中的一些情况。
