Cooper H S, Haesler W E
Am J Clin Pathol. 1978 Jun;69(6):594-8. doi: 10.1093/ajcp/69.6.594.
Adenocarcinomas of the sigmoid colon and rectum were studied for the presence of blood group substances of the A, B, H system using the method of specific erythrocytic adherence. Of 17 adenocarcinomas studied, eight were found to have reactivity for blood group substances. All eight tumours showing reactivity for blood group substances were from patients of the blood group type A, whereas no blood group substances reactivity could be found in any of the adenocarcinomas from patients of the B blood group type. The epithelial cells of the entire colon contain blood group substances in the fetal period; however, shortly after parturition the epithelial cells of the distal colon and rectum rapidly lose the substances. The reappearance of the substances in adenocarcinomas of the distal colon suggests that these neoplastic cells are expressing certain characteristics of fetal colonic epithelial cells.
采用特异性红细胞黏附法，研究了乙状结肠和直肠腺癌中A、B、H血型系统血型物质的存在情况。在所研究的17例腺癌中，发现8例对血型物质有反应性。所有8例显示对血型物质有反应性的肿瘤均来自A型血患者，而B型血患者的腺癌中未发现任何血型物质反应性。整个结肠的上皮细胞在胎儿期含有血型物质；然而，分娩后不久，远端结肠和直肠的上皮细胞迅速失去这些物质。远端结肠腺癌中这些物质的重新出现表明，这些肿瘤细胞正在表达胎儿结肠上皮细胞的某些特征。
