Alich A A, Welsh V J, Wittmers L E
J Pharm Sci. 1983 Dec;72(12):1457-61. doi: 10.1002/jps.2600721222.
The copper salt of aspirin has been compared with aspirin in terms of damage to mucosal tissue. Using a protein-bound dye to highlight erosions, it has been found that copper aspirinate is at least as damaging as aspirin itself. This finding is not in agreement with previously published claims. Copper aspirinate produced more widespread superficial erosions and slightly less deep erosions than aspirin alone. Mixtures of the copper(II) ion and aspirin produced results similar to copper aspirinate, suggesting that the hydrolysis products of copper aspirinate, copper(II) ion and aspirin, together may be especially damaging to the mucosa. Copper alone was not damaging, but aspirin alone yielded intermediate results. Short incubation times produced only erosions (no ulcers), which were clearly differentiated into two classes by depth of color. Histological examination verified this classification into superficial and deep erosions.
就对粘膜组织的损害而言，已将阿司匹林铜盐与阿司匹林进行了比较。使用一种与蛋白质结合的染料来突出糜烂，结果发现阿司匹林铜对组织的损害至少与阿司匹林本身一样大。这一发现与先前发表的说法不一致。与单独使用阿司匹林相比，阿司匹林铜产生的广泛浅表糜烂更多，深度糜烂略少。铜离子（II）与阿司匹林的混合物产生的结果与阿司匹林铜相似，这表明阿司匹林铜的水解产物，即铜离子（II）和阿司匹林，可能共同对粘膜特别具有损害性。单独的铜没有损害作用，但单独的阿司匹林产生的结果居中。短时间孵育仅产生糜烂（无溃疡），根据颜色深度可明显分为两类。组织学检查证实了这种分为浅表和深度糜烂的分类。
