Bardare M, Cislaghi G U, Mandelli M, Sereni F
Arch Dis Child. 1978 May;53(5):381-5. doi: 10.1136/adc.53.5.381.
Plasma salicylate concentration was monitored in 42 children on long-term salicylate therapy for rheumatoid arthritis. A given dose of salicylate per kg resulted in large variations in plasma levels, both between individuals and for a single individual at different times. The factors responsible for such variations were studied; in 6 cases urinary metabolites of salicylate were analysed. The relation between salicylate dosage and plasma half-life accounts for the fact that small changes in dosage can result in large changes in plasma concentration. The addition of corticosteroid or ACTH therapy results in lower plasma levels of salicylate, and necessitates higher dosage of salicylate. After the introduction of routine monitoring of plasma salicylate, the incidence of toxic symptoms fell sharply.
对42名因类风湿性关节炎接受长期水杨酸盐治疗的儿童进行了血浆水杨酸盐浓度监测。每公斤体重给予一定剂量的水杨酸盐后，血浆水平在个体之间以及同一个体在不同时间都有很大差异。对造成这种差异的因素进行了研究；对6例患者的水杨酸盐尿代谢产物进行了分析。水杨酸盐剂量与血浆半衰期之间的关系说明了剂量的微小变化会导致血浆浓度的大幅变化这一事实。添加皮质类固醇或促肾上腺皮质激素治疗会导致血浆水杨酸盐水平降低，因此需要更高剂量的水杨酸盐。在引入血浆水杨酸盐常规监测后，中毒症状的发生率急剧下降。
