κIII免疫球蛋白轻链来源的淀粉样蛋白中的氨基酸序列。

Amino acid sequences in amyloid proteins of kappa III immunoglobulin light-chain origin.

作者信息

Sletten K, Westermark P, Pitkänen P, Thyresson N, Olstad O K

出版信息

Scand J Immunol. 1983 Dec;18(6):557-60. doi: 10.1111/j.1365-3083.1983.tb00891.x.

DOI:10.1111/j.1365-3083.1983.tb00891.x

Abstract

The main amyloid fibril (AL) proteins extracted from the spleen of Patient So 124 with systemic amyloidosis and from a skin nodule of Patient KSA with localized amyloidosis were studied by partial amino acid sequence analysis and proved to be of kappa III immunoglobulin light-chain origin. The sequences were similar to that of Bence Jones protein V and, which has been reported to have a unique kappa III subset sequence. Thus, except for position 9 in protein AL(KSA), the amino acid sequences were identical to position 25 in AL(So 124) and in AL(KSA). The question is being raised whether this kappa III subset might contain amyloidogenic sequences.

摘要

从患有系统性淀粉样变性的患者So 124的脾脏以及患有局限性淀粉样变性的患者KSA的皮肤结节中提取的主要淀粉样原纤维（AL）蛋白，通过部分氨基酸序列分析进行了研究，结果证明其起源于κIII免疫球蛋白轻链。这些序列与本斯·琼斯蛋白V的序列相似，据报道该蛋白具有独特的κIII亚组序列。因此，除了蛋白AL（KSA）中的第9位，其氨基酸序列在AL（So 124）和AL（KSA）中与第25位相同。人们不禁要问，这个κIII亚组是否可能包含淀粉样蛋白生成序列。