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肌肉对正弦长度扰动的张力反应:一项理论研究。

Muscle tension response to sinusoidal length perturbation: a theoretical study.

作者信息

Cheung A S, Gray B F

出版信息

J Muscle Res Cell Motil. 1983 Dec;4(6):615-23. doi: 10.1007/BF00712156.

DOI:10.1007/BF00712156
PMID:6668355
Abstract

The set of kinetic equations that defines a deterministic model of muscle contraction, based on the sliding filament hypothesis in which the relative sliding velocity is an independent variable, is numerically integrated under the simulated conditions of sinusoidal length perturbation. The frequency response curve of phase angle and dynamic stiffness are in agreement with experimental curves. The resultant mean tension per cycle is lower than the unperturbed steady-state tension. The magnitude of the negative tension deviation is greater when either the amplitude or the frequency of the oscillation is increased. The tension-time curve differs from a simple sine when the perturbing frequency is in the vicinity of the stiffness minimum. These consequences are in agreement with the few experimental results that are available.

摘要

基于肌丝滑行假说(其中相对滑行速度是一个自变量)定义肌肉收缩确定性模型的动力学方程组,在正弦长度微扰的模拟条件下进行数值积分。相角和动态刚度的频率响应曲线与实验曲线一致。每个周期的合成平均张力低于未受干扰的稳态张力。当振荡的幅度或频率增加时,负张力偏差的幅度更大。当微扰频率在刚度最小值附近时,张力-时间曲线不同于简单的正弦曲线。这些结果与现有的少数实验结果一致。

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本文引用的文献

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A kinetic model of muscle contraction and its oscillatory characteristics.肌肉收缩的动力学模型及其振荡特性。
J Muscle Res Cell Motil. 1984 Oct;5(5):483-502. doi: 10.1007/BF00713256.
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Energetics and "efficiency" in the isolated contractile machinery of an insect fibrillar muscle at various frequencies of oscillation.昆虫纤维状肌肉的孤立收缩机制在不同振荡频率下的能量学与“效率”
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The coupling of poweroutput and myofibrillar ATPase activity in glycerol-extracted insect fibrillar muscle at varying amplitude of ATP-driven oscillation.在ATP驱动振荡的不同幅度下,甘油提取的昆虫纤维状肌肉中功率输出与肌原纤维ATP酶活性的耦合。
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Head rotation or dissociation? A study of exponential rate processes in chemically skinned rabbit muscle fibers when MgATP concentration is changed.头部旋转还是解离?关于MgATP浓度改变时化学去膜兔肌纤维中指数速率过程的研究。
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