糖尿病性硬化性水肿

Diabetic scleredema.

作者信息

Toyota T, Umezu M, Oikawa N, Sanoyama R, Suzuki S, Suzuki H, Nakajima Y, Goto Y

出版信息

Tohoku J Exp Med. 1983 Dec;141(4):457-61. doi: 10.1620/tjem.141.457.

DOI:10.1620/tjem.141.457

Abstract

Many skin lesions are specific for diabetes mellitus. Necrobiosis lipoidica, lipoatrophy and idiopathic bullae (bullosis diabeticorum) are usually associated with diabetes. However, diabetic scleredema has not been noticed by internists, although dermatologists have paid attention to such a cutaneous manifestation. We reported a clinical case of a female diabetic patient aged 15 who had been afflicted with diabetic scleredema. She had been treated with insulin since 5 years of age. She noticed stiffness of the skin in April 1980. Skin biopsy showed thickness of the dermis and accumulation of acid mucopolysaccharide. After control of blood glucose with continuous subcutaneous insulin infusion (CSII) and administration of tocopherol acetate and hyaluronidase, the skin lesion improved. Etiology of diabetic scleredema is unknown. Such skin lesion which is observed frequently in insulin dependent obese patients is different from a category of scleredema of Buschke.

摘要

许多皮肤病变是糖尿病所特有的。类脂质渐进性坏死、脂肪萎缩和特发性大疱（糖尿病性大疱病）通常与糖尿病相关。然而，尽管皮肤科医生已关注到这种皮肤表现，但内科医生尚未注意到糖尿病性硬化症。我们报告了一例15岁女性糖尿病患者患糖尿病性硬化症的临床病例。她自5岁起就接受胰岛素治疗。1980年4月她注意到皮肤僵硬。皮肤活检显示真皮增厚和酸性粘多糖积聚。在通过持续皮下胰岛素输注（CSII）控制血糖并给予醋酸生育酚和透明质酸酶后，皮肤病变有所改善。糖尿病性硬化症的病因尚不清楚。这种在胰岛素依赖型肥胖患者中经常观察到的皮肤病变不同于Buschke硬化症的范畴。