Morris A I, Little J M, Lester R
Digestion. 1983;28(4):216-24. doi: 10.1159/000198991.
The bile acid pools of developing rats were measured by gas-liquid chromatography. From shortly after birth the bile acid pools fell to a nadir on the 10th day of life (0.295 +/- 0.031 mg X g-1 body weight at 2 days to 0.144 +/- 0.012 mg X g-1 body weight at 10 days, p less than 0.001). The pool re-expanded rapidly between the 12th and 15th day. After weaning and during puberty there was a further temporary increase in pool size, during which females had larger pools than males. By adulthood the pool size had returned to the 2-day-old and weanling (15- and 18-day-old) levels, expressed per gramme body weight, and there was no longer a significant sex difference. These results show that changes in pool size are occurring at times when there are major physiological changes in the developing animal. The changes during puberty suggest hormonal control.
通过气液色谱法测量发育中大鼠的胆汁酸池。从出生后不久开始，胆汁酸池在出生后第10天降至最低点（出生2天时为0.295±0.031mg×g-1体重，到10天时为0.144±0.012mg×g-1体重，p<0.001）。胆汁酸池在第12天至第15天之间迅速重新扩大。断奶后及青春期期间，胆汁酸池大小进一步暂时增加，在此期间雌性的胆汁酸池比雄性的大。到成年时，按每克体重计算，胆汁酸池大小已恢复到出生2天和断奶时（15天和18天）的水平，且不再存在显著的性别差异。这些结果表明，在发育中的动物发生重大生理变化时，胆汁酸池大小会发生变化。青春期的变化提示存在激素调控。
