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关于碱基和碱基序列参与热变性DNA抗原性测定的进一步证据。

Further evidence for the involvement of base and base sequence in the antigenic determination of thermally denatured DNA.

作者信息

Wakizaka A, Okuhara E

出版信息

Tohoku J Exp Med. 1977 Feb;121(2):121-6. doi: 10.1620/tjem.121.121.

DOI:10.1620/tjem.121.121
PMID:66773
Abstract

The antigenic determinant of thermally denatured salmon sperm (ss) DNA was extensively investigated with a radioimmunoassay technique using the ssDNA immune system. It was demonstrated that mixed sequences of purines and pyrimidines play a key role in the antigenic determination of DNA. On the other hand, the importance of the bases in the manifestation of DNA antigenicity was demonstrated by using brominated, methylated and/or ultraviolet irradiated ssDNA preparations.

摘要

利用热变性鲑鱼精子（ss）DNA免疫系统，通过放射免疫分析技术对热变性鲑鱼精子（ss）DNA的抗原决定簇进行了广泛研究。结果表明，嘌呤和嘧啶的混合序列在DNA的抗原决定中起关键作用。另一方面，通过使用溴化、甲基化和/或紫外线照射的ssDNA制剂，证明了碱基在DNA抗原性表现中的重要性。

相似文献

1
Further evidence for the involvement of base and base sequence in the antigenic determination of thermally denatured DNA.关于碱基和碱基序列参与热变性DNA抗原性测定的进一步证据。
Tohoku J Exp Med. 1977 Feb;121(2):121-6. doi: 10.1620/tjem.121.121.
2
Immunochemical studies on the correlation between conformational changes of DNA caused by ultraviolet irradiation and manifestation of antigenicity.关于紫外线照射引起的DNA构象变化与抗原性表现之间相关性的免疫化学研究。
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The role of nucleotide sequence in the immune-active structure photochemically induced in double-stranded DNA by ultraviolet irradiation.核苷酸序列在紫外线照射双链DNA光化学诱导的免疫活性结构中的作用。
J Biochem. 1982 Sep;92(3):757-63. doi: 10.1093/oxfordjournals.jbchem.a133987.
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Immunological studies on nucleic acids: an investigation of the antigenic determinants of denatured deoxyribonucleic acid (DNA) reactive with rabbit anti-DNA antisera by a radioimmunoassay technique.
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Antigenic structure of DNA: relatively high inhibitory activity of di- and trideoxyribonucleotide derived from DNase digest on the interaction of thermally denatured DNA with systemic lupus erythematosus sera.DNA的抗原结构：脱氧核糖核酸酶消化产生的二脱氧核糖核苷酸和三脱氧核糖核苷酸对热变性DNA与系统性红斑狼疮血清相互作用具有较高的抑制活性。
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Antigenicity of methylated deoxyribonucleic acid.
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The length of repetitive sequences of monkey cell and salmon sperm DNA.猴细胞和鲑鱼精子DNA重复序列的长度。
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Origin of ultraviolet damage in DNA.DNA中紫外线损伤的起源。
J Mol Biol. 1989 Dec 5;210(3):429-38. doi: 10.1016/0022-2836(89)90120-4.
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Secondary structure in denatured DNA is responsible for its reaction with antinative DNA antibodies of systemic lupus erythematosus sera.变性DNA中的二级结构是其与系统性红斑狼疮血清中的抗天然DNA抗体发生反应的原因。
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Immunology. 1976 May;30(5):635-9.

引用本文的文献

1
Antigenic structure of DNA: relatively high inhibitory activity of di- and trideoxyribonucleotide derived from DNase digest on the interaction of thermally denatured DNA with systemic lupus erythematosus sera.DNA的抗原结构：脱氧核糖核酸酶消化产生的二脱氧核糖核苷酸和三脱氧核糖核苷酸对热变性DNA与系统性红斑狼疮血清相互作用具有较高的抑制活性。
Clin Exp Immunol. 1981 Feb;43(2):223-30.