Svendsen U G
Scand J Rheumatol. 1979;8(2):81-6. doi: 10.3109/03009747909105341.
Treatment with penicillamine was capable of bringing down the elevated systemic arterial pressure in the thymus-dependent phase of infarct-kidney hypertension in mice; a marked improvement in the clinical condition of the treated animals was observed as compared with untreated hypertensive mice. No pathological changes in either kidney or heart could be attributed to toxic side effects of penicillamine either in normotensive or in hypertensive mice treated for several months with penicillamine. It is concluded that penicillamine may have an effect on thymus-dependent reactions, such as the increased blood pressure in the chronic phase of infarct-kidney hypertension in mice. In mice, the treatment can be extended over a considerable part of the animal's life span without apparently giving rise to toxic side effects on vital organs.
用青霉胺治疗能够降低小鼠梗死肾性高血压胸腺依赖期升高的体循环动脉压；与未治疗的高血压小鼠相比，观察到治疗动物的临床状况有明显改善。在正常血压或用青霉胺治疗数月的高血压小鼠中，肾脏和心脏均未发现可归因于青霉胺毒性副作用的病理变化。结论是，青霉胺可能对胸腺依赖反应有影响，例如小鼠梗死肾性高血压慢性期血压升高。在小鼠中，这种治疗可以延长至动物寿命的相当一部分时间，而显然不会对重要器官产生毒性副作用。
