Denekamp J, Hill S A, Hobson B
Eur J Cancer Clin Oncol. 1983 Feb;19(2):271-5. doi: 10.1016/0277-5379(83)90426-1.
Vascular occlusion has been tested as a means of inducing regrowth delay, local control, reduced cell viability and prolonged alteration of blood flow in mouse tumours. The occlusion has been achieved by applying D-shaped metal clamps across the base of subcutaneously implanted tumours. The period of clamping has been varied from 30 min to 24 hr. Marked tumour regression, delayed growth and long-term tumour control were seen, with the magnitude of the response being proportional to the duration of clamping. Vessel occlusion for at least 15 hr is necessary to achieve local cure of the tumour. The overall effect results partly from an immediate loss of cell viability and partly from a failure of the capillary network to recover its normal perfusion pattern after the clamp has been removed. The implications of this for anti-proliferative endothelial therapy is discussed.
血管闭塞已作为一种诱导小鼠肿瘤再生长延迟、局部控制、降低细胞活力和延长血流改变的方法进行了测试。通过在皮下植入肿瘤的基部应用D形金属夹来实现闭塞。夹闭时间从30分钟到24小时不等。观察到明显的肿瘤消退、生长延迟和长期肿瘤控制，反应程度与夹闭持续时间成正比。血管闭塞至少15小时对于实现肿瘤的局部治愈是必要的。总体效果部分源于细胞活力的立即丧失，部分源于在夹子移除后毛细血管网络未能恢复其正常灌注模式。讨论了这对于抗增殖内皮治疗的意义。
