Melnick M, Marazita M, Jaskoll T
Immunogenetics. 1983;17(2):141-6. doi: 10.1007/BF00364754.
Different strains of H-2 congenic mice have different susceptibilities to corticosteroid-induced fetal loss and cleft palate. Applying this knowledge, we tested the null hypothesis, which assumes that there are no statistically significant differences in the frequency of abnormality among various types of treated backcross offspring and, thus, no evidence of a cytoplasmic effect. In the present study this null hypothesis was frequently, but not consistently, rejected. Therefore, there was some evidence of a cytoplasmic effect. One possible explanation of these results is seen when one considers the phenotypic effects of "gene-gene interaction" between variant H-2 genotypes and an invariant mitochondrial genotype.
不同品系的H-2同源基因小鼠对皮质类固醇诱导的胎儿丢失和腭裂具有不同的易感性。运用这一知识，我们检验了零假设，该假设假定在各种经处理的回交后代类型中，异常频率不存在统计学上的显著差异，因此不存在细胞质效应的证据。在本研究中，这一零假设经常（但并非始终）被拒绝。因此，有一些细胞质效应的证据。当考虑变异的H-2基因型与不变的线粒体基因型之间“基因-基因相互作用”的表型效应时，可以看到这些结果的一种可能解释。
