小鼠对苯妥英钠诱导的腭裂易感性受与H-2和H-3相关基因的影响。
Susceptibility to phenytoin-induced cleft palate in mice is influenced by genes linked to H-2 and H-3.
作者信息
Goldman A S, Baker M K, Gasser D L
出版信息
Immunogenetics. 1983;18(1):17-22. doi: 10.1007/BF00401352.
PMID:6862529
Abstract
Pregnant female mice of various congenic strains were injected on days 11 through 14 of gestation with phenytoin, and the fetuses were examined for the occurrence of cleft palate. The pattern of susceptibility indicates that two genes in the H-2 complex and another gene linked to H-3 are involved in the determination of this trait.
摘要
在妊娠第11天至14天，给不同近交系的怀孕雌性小鼠注射苯妥英钠，然后检查胎儿是否出现腭裂。易感性模式表明，H-2复合体中的两个基因以及与H-3连锁的另一个基因参与了这一性状的决定。
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