小鼠中影响对可的松诱导腭裂易感性的基因与2号和17号染色体上的Ir基因紧密连锁。
Genes in mice that affect susceptibility to cortisone-induced cleft palate are closely linked to Ir genes on chromosomes 2 and 17.
作者信息
Gasser D L, Mele L, Lees D D, Goldman A S
出版信息
Proc Natl Acad Sci U S A. 1981 May;78(5):3147-50. doi: 10.1073/pnas.78.5.3147.
Abstract
Inbred and congeneic strains of mice have been examined for susceptibility to cortisone-induced cleft palate, and the role of genes linked to H-2 on chromosome 17 has been confirmed. Increasing degrees of susceptibility were associated with the H-2d, H-2b, H-2k, and H-2a haplotypes, respectively, with H-2q and H-2s also being associated with fairly high levels of susceptibility. Evidence was obtained that suggests that one gene maps within the B region of H-2, and that a second H-2 linked gene which acts by complementation maps to the right of E. Another gene affecting this trait is closely linked to the H-3 and Ir-2 loci on the second chromosome.
摘要
已对近交系和同源近交系小鼠进行了可的松诱导腭裂易感性的检测，并证实了与17号染色体上H-2相关基因的作用。易感性程度的增加分别与H-2d、H-2b、H-2k和H-2a单倍型相关，H-2q和H-2s也与相当高的易感性水平相关。有证据表明，一个基因定位于H-2的B区域内，另一个通过互补作用的与H-2连锁的基因定位于E的右侧。另一个影响该性状的基因与第二条染色体上的H-3和Ir-2位点紧密连锁。
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