妊娠期导致淋巴细胞活性降低的两种血清因子的检测与分离。
Detection and separation of two serum factors responsible for depression of lymphocyte activity in pregnancy.
作者信息
Clarke F M, Morton H, Clunie G J
出版信息
Clin Exp Immunol. 1978 May;32(2):318-23.
Abstract
Studies using the rosette inhibition test have demonstrated a depression of lymphocyte activity in pregnant mice which occurs as early as 6 hr after fertilization and persists until just before delivery. This depression of lymphocyte activity is induced by two serum factors, the relative contributions of which vary with the time of gestation. The first, a high molecular weight early pregnancy factor, appears within hours of fertilization and then slowly declines in activity as gestation proceeds. The second, a lower molecular weight substance which cross-reacts with antiserum to human chorionic gonadotrophin, appears after the formation of the trophoblast at 4--5 days and persists until parturition.
摘要
使用玫瑰花结抑制试验的研究表明，怀孕小鼠的淋巴细胞活性受到抑制，这种抑制早在受精后6小时就会出现，并一直持续到分娩前。淋巴细胞活性的这种抑制是由两种血清因子诱导的，它们的相对作用随妊娠期的时间而变化。第一种是高分子量的早期妊娠因子，在受精后数小时内出现，然后随着妊娠的进展其活性逐渐缓慢下降。第二种是分子量较低的物质，它与抗人绒毛膜促性腺激素抗血清发生交叉反应，在4 - 5天滋养层形成后出现，并一直持续到分娩。
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本文引用的文献
1
Mammogenic activities of the midgestational mouse placenta.妊娠中期小鼠胎盘的生乳活性。
Endocrinology. 1960 Dec;67:884-7. doi: 10.1210/endo-67-6-884.
2
The isolation and partial characterisation of a new alpha-macroglobulin from human pregnancy serum.从人妊娠血清中分离并部分鉴定一种新的α-巨球蛋白。
FEBS Lett. 1972 Jul 1;23(3):298-302. doi: 10.1016/0014-5793(72)80301-6.
3
Effect of human chorionic gonadotropin on in vitro lymphocyte transformation.人绒毛膜促性腺激素对体外淋巴细胞转化的影响。
Am J Obstet Gynecol. 1971 Apr 1;109(7):1029-31. doi: 10.1016/0002-9378(71)90285-7.
4
Immunological responses in pregnancy and survival of fetal homograft.妊娠中的免疫反应与胎儿同种移植物的存活
Br Med J. 1972 Jul 15;3(5819):150-2. doi: 10.1136/bmj.3.5819.150.
5
In vitro rosette inhibition by antihuman antilymphocyte serum. Correlation with skin graft prolongation in subhuman primates.抗人抗淋巴细胞血清的体外玫瑰花结抑制作用。与亚人类灵长类动物皮肤移植延长的相关性。
Transplantation. 1969 Sep;8(3):265-80. doi: 10.1097/00007890-196909000-00008.
6
Clinical evaluation of a rosette inhibition test in renal allotransplantation.肾同种移植中玫瑰花结抑制试验的临床评估
Br Med J. 1971 Jul 31;3(5769):271-6. doi: 10.1136/bmj.3.5769.271.
7
Human chorionic gonadotropin: inhibitory effect on mixed lymphocyte cultures.人绒毛膜促性腺激素：对混合淋巴细胞培养的抑制作用。
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