运动应激对淋巴细胞转化和抗体形成的影响。
Effect of sport stress on lymphocyte transformation and antibody formation.
作者信息
Eskola J, Ruuskanen O, Soppi E, Viljanen M K, Järvinen M, Toivonen H, Kouvalainen K
出版信息
Clin Exp Immunol. 1978 May;32(2):339-45.
The effect of a heavy (marathon, 2.5 hr) and moderate (35 min of running) sport stress on the number and function of lymphocytes, and on the plasma cortisol and leucocyte levels was investigated. Marathon running had a profound effect on the lymphocytes. Though the total number of lymphocytes did not change, their responsiveness to PHA and Con A, especially to PPD, was clearly depressed. The suppression of lymphocyte transformation was transient, the recovery occurring in 24 hr. The marathon running had no effect on antibody-forming capacity when the antigen was given immediately after the performance of the marathon, i.e. at the time when the response of lymphocytes to PHA, Con A and PPD stimulation was impaired. A clear-cut granulocytosis and elevation of plasma cortisol was seen in all the marathon runners. The 35 min of running also resulted in granulocytosis and an increase of plasma cortisol, but it did not cause any impairment of the lymphocyte function.
研究了高强度（马拉松，2.5小时）和中等强度（跑步35分钟）运动应激对淋巴细胞数量和功能、血浆皮质醇水平及白细胞水平的影响。马拉松跑步对淋巴细胞有深远影响。虽然淋巴细胞总数未变，但其对PHA和Con A，尤其是对PPD的反应性明显降低。淋巴细胞转化的抑制是短暂的，24小时内即可恢复。马拉松跑步后立即给予抗原时，即淋巴细胞对PHA、Con A和PPD刺激的反应受损时，对抗体形成能力没有影响。所有马拉松运动员均出现明显的粒细胞增多和血浆皮质醇升高。35分钟的跑步也导致粒细胞增多和血浆皮质醇增加，但未引起淋巴细胞功能的任何损害。
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