Mardones J, Segovia-Riquelme N
Neurobehav Toxicol Teratol. 1983 Mar-Apr;5(2):171-8.
An overview of the development of two strains of rats with low and high consumption of ethanol is reported. Voluntary consumption of water and various concentrations of ethanol solution were studied in these strains as a function of diet, supplementation with vitamin B complex components, housing conditions and coefficient of heredity. Both distribution factor of the consumption of ethanol in hybrids and the course of voluntary intake of ethanol have been described. In addition, a comparison was made between these rat strains developed for low and high preference to ethanol drinking in reference to their voluntary intake of ethanol, water and food. The metabolic concomitant to these two strains has been studied in relationship to ethanol metabolism and to other substrates, i.e., acetate, pyruvate, glucose, citrate and fructose. Behavioral studies were also performed. This included the measurements of duration of ethanol narcosis and evaluation of tolerance to ethanol drinking.
本文报道了两种乙醇消耗量低和高的大鼠品系的发育概况。研究了这些品系中作为饮食、复合维生素B成分补充、饲养条件和遗传系数函数的水和各种浓度乙醇溶液的自愿消耗量。描述了杂种中乙醇消耗的分布因子以及乙醇自愿摄入量的过程。此外，还比较了这两种为低乙醇饮用偏好和高乙醇饮用偏好而培育的大鼠品系在乙醇、水和食物自愿摄入量方面的差异。研究了与这两种品系相关的代谢情况，涉及乙醇代谢以及其他底物，即乙酸盐、丙酮酸盐、葡萄糖、柠檬酸盐和果糖。还进行了行为学研究。这包括测量乙醇麻醉的持续时间以及评估对乙醇饮用的耐受性。
