Belova T I, Iunson Iu
Biull Eksp Biol Med. 1983 Jul;96(7):3-4.
Intravenous injection of trypan blue followed by treatment of the brain according to the Falc-Hillarp was used for morphological study of the blood-brain barrier in control rats and in animals exposed to the 6.5-hour stress. The density of the blood-brain barrier as regards the macromolecules in control animals was found to be liable to noticeable areal variations. The zones of primary increased barrier permeability were found near the basal surface of the brain. Prolonged single immobilization stress gave rise to destructive changes in the blood-brain barrier in the reticular formations of the midbrain and medulla oblongata. Besides, in control animals, there was a slight increase in permeability of the brain areas marked by the reduced barrier density.
给对照大鼠和遭受6.5小时应激的动物静脉注射台盼蓝，然后按照法尔克 - 希拉尔普法处理大脑，用于血脑屏障的形态学研究。发现对照动物中血脑屏障对大分子的密度存在明显的区域差异。在脑基底面附近发现了血脑屏障通透性最初增加的区域。长时间的单次固定应激导致中脑和延髓网状结构中的血脑屏障出现破坏性变化。此外，在对照动物中，屏障密度降低的脑区通透性略有增加。
