Dinsdale J R, Griffiths G K, Castelló J, Maddock J, Ortiz J A, Aylward M
Arzneimittelforschung. 1983;33(7A):1061-5.
Cytidine diphosphate choline (CDP-choline, citicoline, Somazina) was administered to 12 adult healthy volunteer subjects in two short-term chronic oral dose regimens (600 mg X day-1 and 1g X day-1), each of 5 consecutive days, and compared with a corresponding regimen of matched placebo. Transient headaches were the only untoward events recorded, occurring in 4 and 5 subjects, respectively, on the lower and higher dose regimens but in only one subject during placebo administration.
对12名成年健康志愿者进行了胞苷二磷酸胆碱（CDP - 胆碱、西替考林、索马西纳）的给药，采用两种短期慢性口服给药方案（600毫克×每日 -1和1克×每日 -1），每种方案连续给药5天，并与相应的匹配安慰剂方案进行比较。记录到的唯一不良事件是短暂性头痛，分别有4名和5名受试者在较低和较高剂量方案中出现头痛，但在安慰剂给药期间只有1名受试者出现头痛。
