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从寄生虫提取物中分离出的含磷酰胆碱成分对C反应蛋白阳性血清中补体的激活作用。

Activation of complement in C-reactive protein positive sera by phosphorylcholine-bearing component isolated from parasite extract.

作者信息

Sugane K, Oshima T

出版信息

Parasite Immunol. 1983 Jul;5(4):385-95. doi: 10.1111/j.1365-3024.1983.tb00754.x.

DOI:10.1111/j.1365-3024.1983.tb00754.x
PMID:6684760
Abstract

Phosphorylcholine-bearing component levels in extracts of various parasites were determined by a capillary precipitin test using anti-phosphorylcholine Ig A myeloma protein. TEPC-15. Phosphorylcholine was demonstrated as a structural component not only in nematodes but also in trematodes and cestodes. The phosphorylcholine-bearing component was isolated from an extract of Toxocara canis larvae using a TEPC-15-Sepharose 4B column. The component reacted with C-reactive protein in sera to form one precipitin line in immunoelectrophoresis. The component provided two Brilliant Coomassie Blue positive bands in SDS-polyacrylamide gel electrophoresis. It reacted with C-reactive protein to activate complement in serum.

摘要

使用抗磷酸胆碱IgA骨髓瘤蛋白TEPC - 15，通过毛细管沉淀试验测定各种寄生虫提取物中含磷酸胆碱成分的水平。磷酸胆碱不仅被证明是线虫的结构成分，也是吸虫和绦虫的结构成分。使用TEPC - 15 - 琼脂糖4B柱从犬弓首蛔虫幼虫提取物中分离出含磷酸胆碱的成分。该成分在免疫电泳中与血清中的C反应蛋白反应形成一条沉淀线。该成分在SDS - 聚丙烯酰胺凝胶电泳中呈现两条考马斯亮蓝阳性带。它与C反应蛋白反应以激活血清中的补体。

相似文献

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Activation of complement in C-reactive protein positive sera by phosphorylcholine-bearing component isolated from parasite extract.从寄生虫提取物中分离出的含磷酰胆碱成分对C反应蛋白阳性血清中补体的激活作用。
Parasite Immunol. 1983 Jul;5(4):385-95. doi: 10.1111/j.1365-3024.1983.tb00754.x.
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