Lindbohm M L, Hemminki K, Kyyrönen P, Kilpikari I, Vainio H
Scand J Work Environ Health. 1983;9 Suppl 2:85-90.
Spontaneous abortions of hospitalized women and congenital malformations were analyzed among rubber workers to investigate the possibility of an association between reproductive problems and chemical exposures in the rubber industry. Information on workers was obtained from the membership register of the Union of Rubber and Leather Workers and from the personnel register of a rubber factory. The frequencies of spontaneous abortions did not appreciably differ when the pregnancies occurred during Union membership or during employment in the factory as compared with the pregnancies occurring before or after that time. A case-referent study concerning the association between different exposures and spontaneous abortions showed that the odds ratio for factory workers exposed to rubber chemicals was increased in the footwear department. A corresponding risk was not observed in the tire department. The contradictory observations may be explained by concomitant exposure to solvents in the footwear department or by other nonoccupational factors. The possible association between congenital malformations and exposures in the rubber and leather industries was studied by the case-referent technique. No significant increase in the risk of malformations was observed in any branch of employment. However, the numbers of malformations were rather small.
对住院女性橡胶工人的自然流产和先天性畸形进行了分析，以调查橡胶行业生殖问题与化学物质暴露之间存在关联的可能性。有关工人的信息来自橡胶和皮革工人联盟的会员登记册以及一家橡胶厂的人事登记册。与在该时间段之前或之后发生的妊娠相比，妊娠发生在工会会员期间或工厂就业期间时，自然流产的频率没有明显差异。一项关于不同暴露与自然流产之间关联的病例对照研究表明，在鞋类部门，接触橡胶化学品的工厂工人的比值比有所增加。在轮胎部门未观察到相应风险。这些相互矛盾的观察结果可能是由于鞋类部门同时接触溶剂或其他非职业因素所致。采用病例对照技术研究了橡胶和皮革行业先天性畸形与暴露之间的可能关联。在任何就业部门均未观察到畸形风险显著增加。然而，畸形的数量相当少。
