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Antimicrob Agents Chemother. 1983 Oct;24(4):611-2. doi: 10.1128/AAC.24.4.611.
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Lack of efficacy of 2-deoxy-D-glucose in the treatment of experimental herpes genitalis in guinea pigs.2-脱氧-D-葡萄糖治疗豚鼠实验性生殖器疱疹无效。
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本文引用的文献

1
Effects of adenosine monophosphate on the reactivation of latent herpes simplex virus type 1 infections of mice.单磷酸腺苷对小鼠潜伏性单纯疱疹病毒1型感染再激活的影响。
Antimicrob Agents Chemother. 1981 Oct;20(4):547-8. doi: 10.1128/AAC.20.4.547.
2
Herpes zoster.带状疱疹
Br J Dermatol. 1981 Mar;104(3):351-2. doi: 10.1111/j.1365-2133.1981.tb00964.x.

在豚鼠中，AMP对复发性生殖器疱疹感染缺乏疗效。

Lack of efficacy of AMP against recrudescent genital herpes infections in guinea pigs.

作者信息

Fraser-Smith E B, Smee D F, Matthews T R

出版信息

Antimicrob Agents Chemother. 1983 Oct;24(4):611-2. doi: 10.1128/AAC.24.4.611.

DOI:10.1128/AAC.24.4.611
PMID:6685993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185385/
Abstract

AMP was evaluated for its efficacy against herpes simplex virus type 2 genital infections in guinea pigs. Vaginally infected animals were treated twice a day with AMP at 50 mg/kg per dose for 2 weeks. Subcutaneous doses were started 10 weeks postinfection. AMP treatment did not reduce the number of animals with recrudescent episodes when compared with saline-treated controls. In addition, AMP treatment did not reduce either the number of lesions or the duration of the recrudescent episodes which did develop. These results suggest that AMP has no effect on recrudescent herpes simplex virus type 2 vaginal infections.

摘要

对氨甲蝶呤（AMP）抗豚鼠2型单纯疱疹病毒生殖器感染的疗效进行了评估。经阴道感染的动物每天接受两次AMP治疗，剂量为50毫克/千克，持续2周。皮下给药在感染后10周开始。与生理盐水处理的对照组相比，AMP治疗并未减少复发发作动物的数量。此外，AMP治疗既未减少出现的病变数量，也未缩短复发发作的持续时间。这些结果表明，AMP对2型单纯疱疹病毒复发性阴道感染没有作用。