豚鼠模型中的生殖器疱疹：发病机制与化疗

Genital herpes: pathogenesis and chemotherapy in the guinea pig model.

作者信息

Hsiung G D, Mayo D R, Lucia H L, Landry M L

出版信息

Rev Infect Dis. 1984 Jan-Feb;6(1):33-50. doi: 10.1093/clinids/6.1.33.

DOI:10.1093/clinids/6.1.33

Abstract

Genital herpes is different from other common venereal diseases in that there is no cure. As yet the natural history of genital herpes is not well understood. There are many unanswered questions regarding the biology of the disease; the virulence of the virus strains, individual host responses, and means for prevention and control all require further investigation. The study of genital herpes has been greatly aided in recent years by the development of animal models. The clinical and pathologic features of acute and recurrent genital disease of guinea pigs inoculated with low doses of herpes simplex virus are similar to those seen in human infection. Therefore, questions not readily studied in human infection--such as latent infection in the nervous system, the natural history, prevention, and treatment of neonatal herpes, the effects of immunosuppression on herpes infection, and the efficacy and toxicity of antiviral drugs and vaccines--are amenable to study in the guinea pig model. The applications of this animal model and its relevance to human disease are herein reviewed.

摘要

生殖器疱疹与其他常见性病不同，在于它无法治愈。目前，生殖器疱疹的自然病程尚未完全明了。关于该疾病的生物学特性，存在许多未解决的问题；病毒株的毒力、个体宿主反应以及预防和控制手段都需要进一步研究。近年来，动物模型的发展极大地促进了生殖器疱疹的研究。用低剂量单纯疱疹病毒接种的豚鼠急性和复发性生殖器疾病的临床和病理特征与人类感染所见相似。因此，在人类感染中不易研究的问题——如神经系统的潜伏感染、新生儿疱疹的自然病程、预防和治疗、免疫抑制对疱疹感染的影响以及抗病毒药物和疫苗的疗效和毒性——都适合在豚鼠模型中进行研究。本文综述了这种动物模型的应用及其与人类疾病的相关性。