2-脱氧-D-葡萄糖治疗豚鼠实验性生殖器疱疹无效。
Lack of efficacy of 2-deoxy-D-glucose in the treatment of experimental herpes genitalis in guinea pigs.
作者信息
Shannon W M, Arnett G, Drennen D J
出版信息
Antimicrob Agents Chemother. 1982 Mar;21(3):513-5. doi: 10.1128/AAC.21.3.513.
Abstract
Topical treatment of herpes genitalis in female guinea pigs with 2-deoxy-D-glucose in either agarose gels or miconazole nitrate ointments failed to prevent the development of genital lesions or to reduce the mean titers of recoverable virus in vaginal swabs from infected animals. In contrast, phosphonoacetic acid was therapeutically effective.
摘要
在雌性豚鼠中，用琼脂糖凝胶或硝酸咪康唑软膏中的2-脱氧-D-葡萄糖对生殖器疱疹进行局部治疗，未能预防生殖器病变的发生，也未能降低受感染动物阴道拭子中可恢复病毒的平均滴度。相比之下，膦甲酸具有治疗效果。
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本文引用的文献
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JAMA. 1980 Jan 4;243(1):29-30.
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Antiviral agents as adjuncts in cancer chemotherapy.抗病毒药物作为癌症化疗的辅助药物。
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Glucose analogues in the chemotherapy of herpesvirus infections.葡萄糖类似物在疱疹病毒感染化疗中的应用。
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Inhibition of herpes virus-induced cell fusion by concanavalin A, antisera, and 2-deoxy-D-glucose.伴刀豆球蛋白A、抗血清和2-脱氧-D-葡萄糖对疱疹病毒诱导的细胞融合的抑制作用。
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Effect of 2-deoxy-D-glucose on cell fusion induced by Newcastle disease and herpes simplex viruses.2-脱氧-D-葡萄糖对新城疫病毒和单纯疱疹病毒诱导的细胞融合的影响。
Virology. 1973 Sep;55(1):193-201. doi: 10.1016/s0042-6822(73)81021-9.
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Virology. 1973 Apr;52(2):447-55. doi: 10.1016/0042-6822(73)90340-1.
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