链格孢菌代谢产物交链孢酚、交链孢酚单甲醚、细交链孢菌酮酸和链格孢菌毒素在鸡胚试验中的毒性。
Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay.
作者信息
Griffin G F, Chu F S
出版信息
Appl Environ Microbiol. 1983 Dec;46(6):1420-2. doi: 10.1128/aem.46.6.1420-1422.1983.
Abstract
The effects in the chicken embryo assay of four Alternaria metabolites (alternariol [AOH], alternariol methyl ether [AME], altenuene [ALT], and tenuazonic acid [TA]) were investigated. Administered to 7-day-old chicken embryos by yolk sac injection, AOH, AME, and ALT caused no mortality or teratogenic effect at doses up to 1,000, 500, and 1,000 micrograms per egg, respectively. TA exhibited a calculated 50% lethal dose of 548 micrograms per egg, with no teratogenic effect observed at either lethal or sublethal doses.
摘要
研究了四种链格孢属代谢产物（交链孢酚[AOH]、交链孢酚单甲醚[AME]、细交链孢菌酮酸[ALT]和链格孢毒素[TA]）在鸡胚试验中的作用。通过卵黄囊注射给予7日龄鸡胚，AOH、AME和ALT分别在每枚鸡蛋高达1000、500和1000微克的剂量下未引起死亡或致畸作用。TA的计算半数致死剂量为每枚鸡蛋548微克，在致死剂量和亚致死剂量下均未观察到致畸作用。
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