Szikszay M, Benedek G, Obál F
Life Sci. 1983;33 Suppl 1:377-80. doi: 10.1016/0024-3205(83)90521-0.
Thermoregulatory reactions to warm exposure and naloxone treatment, as well as behavioral reactions to morphine withdrawal, were recorded in morphine tolerant rats after capsaicin pretreatment. Enhanced behavioural reactions to morphine withdrawal were found in capsaicin pretreated rats, although no differences in degree of withdrawal hypothermia were seen. Morphine tolerant rats displayed increased thermal tolerance; this was partially prevented by capsaicin pretreatment. The results provide further evidence concerning the interference of neural mechanisms sensitive to capsaicin and opiates.
在辣椒素预处理后的吗啡耐受大鼠中，记录了对热暴露和纳洛酮治疗的体温调节反应，以及对吗啡戒断的行为反应。尽管在戒断性体温过低的程度上未观察到差异，但在辣椒素预处理的大鼠中发现对吗啡戒断的行为反应增强。吗啡耐受大鼠表现出热耐受性增加；辣椒素预处理可部分阻止这种情况。这些结果为辣椒素和阿片类药物敏感的神经机制的干扰提供了进一步的证据。
