Benedek G, Szikszay M, Obál F
Life Sci. 1983;33 Suppl 1:591-3. doi: 10.1016/0024-3205(83)90572-6.
Body temperature reactions to morphine were tested in freely-moving adult rats reared without any previous experience to human handling. These animals reacted to 8 mg/kg morphine s.c. with a biphasic hypo-hyperthermic response. When the rats had been handled for six days, the same dose of morphine induced a monophasic hyperthermic reaction. The results are regarded as evidence that stress-related factors interfere with the thermoregulatory effects of morphine.
在未经任何与人类接触的前期经历的自由活动成年大鼠中测试了对吗啡的体温反应。这些动物对皮下注射8mg/kg吗啡呈现双相的低温-高温反应。当大鼠经过6天的处理后，相同剂量的吗啡诱发单相高温反应。这些结果被视为应激相关因素干扰吗啡体温调节作用的证据。
