Watanabe N, Shimada H
Cell Differ. 1983 Nov;13(3):239-45. doi: 10.1016/0045-6039(83)90095-7.
The effects of the inhibition of protein synthesis by emetine on the initiation of DNA synthesis and mitosis in the fertilized eggs of the sea urchin, Anthocidaris crassispina, were studied. The initiation of DNA synthesis was completely prevented, and no delayed initiation was observed in eggs in which protein synthesis was completely inhibited by emetine, while delayed initiation of DNA synthesis occurred after prolonged culture in eggs in which protein synthesis was incompletely inhibited by emetine. In both cases, neither mitosis nor cleavage was observed. Synthesis of some protein factor seems to be necessary for the initiation of DNA synthesis.
研究了依米丁抑制蛋白质合成对厚刺海胆受精卵中DNA合成起始和有丝分裂的影响。依米丁完全抑制蛋白质合成时，DNA合成起始被完全阻止，未观察到延迟起始；而依米丁不完全抑制蛋白质合成时，受精卵经长时间培养后会出现DNA合成延迟起始。在这两种情况下，均未观察到有丝分裂或卵裂。DNA合成起始似乎需要某些蛋白质因子的合成。
