Pasternak J F, Groothuis D R
Biol Neonate. 1985;48(2):100-9. doi: 10.1159/000242160.
Regional cerebral blood flow (RCBF) was measured in 17 newborn beagle puppies under conditions of moderate hypotension, normotension, and moderate hypertension. RCBF demonstrated autoregulation over the blood pressure range 35-70 mm Hg. When arterial pressure exceeded 75 mm Hg, RCBF increased significantly for all grey matter structures, 2 of 4 white matter structures, and 2 of 3 germinal matrix structures. The magnitude of the hypertension-induced increase in RCBF was highest for thalamic and mesencephalic nuclei, intermediate in cerebral cortex and other subcortical nuclei, and lowest in white matter. The hypertension-induced increase in CBF was low (similar to white matter) in some areas of germinal matrix but higher (similar to midline cerebral cortex) to rostral germinal matrix. The differences in RCBF during hypertension between rostral germinal matrix and cerebral white matter may partially explain the vulnerability of the germinal matrix to hemorrhage.
在17只新生比格犬幼犬处于中度低血压、正常血压和中度高血压状态下，测量了局部脑血流量（RCBF）。RCBF在35 - 70毫米汞柱的血压范围内表现出自动调节功能。当动脉压超过75毫米汞柱时，所有灰质结构、4个白质结构中的2个以及3个生发基质结构中的2个的RCBF显著增加。高血压引起的RCBF增加幅度在丘脑和中脑核中最高，在大脑皮层和其他皮层下核中居中，在白质中最低。高血压引起的CBF增加在生发基质的某些区域较低（类似于白质），但在生发基质的前部较高（类似于中线大脑皮层）。生发基质前部与脑白质在高血压期间RCBF的差异可能部分解释了生发基质易出血的原因。
