年龄和性别对肠胰多肽对口服葡萄糖反应的影响。

The effect of age and sex on the response of enteropancreatic polypeptides to oral glucose.

作者信息

McConnell J G, Alam M J, O'Hare M M, Buchanan K D, Stout R W

出版信息

Age Ageing. 1983 Feb;12(1):54-62. doi: 10.1093/ageing/12.1.54.

DOI:10.1093/ageing/12.1.54

Abstract

Enteropancreatic polypeptide responses during a 50 g oral glucose tolerance test were studied in 10 young men, 10 young women, 10 elderly men and 10 elderly women. Elderly females had higher gastric inhibitory polypeptide (GIP) responses to oral glucose than elderly males. Elderly males and females had higher fasting and post-glucose human pancreatic polypeptide (HPP) levels than young males and females. N-Glucagon-like immunoreactivity (N-GLI) responses differed between the young and elderly. In the young, N-GLI levels fell after oral glucose but in the elderly they rose. Post-glucose C-glucagon-like immunoreactivity (C-GLI) responses were higher in elderly females than in young females. The significance of the higher plasma levels of GIP, N-GLI and C-GLI following oral glucose in elderly females compared to elderly males is unclear.

摘要

在10名年轻男性、10名年轻女性、10名老年男性和10名老年女性中研究了50克口服葡萄糖耐量试验期间的肠胰多肽反应。老年女性对口服葡萄糖的胃抑制多肽（GIP）反应高于老年男性。老年男性和女性的空腹及葡萄糖后人类胰多肽（HPP）水平高于年轻男性和女性。年轻和老年人群的N-胰高血糖素样免疫反应性（N-GLI）反应有所不同。在年轻人中，口服葡萄糖后N-GLI水平下降，但在老年人中则上升。葡萄糖后C-胰高血糖素样免疫反应性（C-GLI）反应在老年女性中高于年轻女性。与老年男性相比，老年女性口服葡萄糖后GIP、N-GLI和C-GLI血浆水平较高的意义尚不清楚。