葡萄糖耐量与衰老
Glucose tolerance and ageing.
作者信息
Stout R W
机构信息
Department of Geriatric Medicine, Queen's University of Belfast, Northern Ireland, UK.
出版信息
J R Soc Med. 1994 Oct;87(10):608-9. doi: 10.1177/014107689408701015.
Abstract
Hyperglycaemia, impaired glucose tolerance and noninsulin dependent diabetes become progressively more common with advancing age. The mechanism is insensitivity to the actions of insulin at the postreceptor level. Inadequate secretion of insulin and decreased hepatic sensitivity to insulin's action in suppressing glucose output also occur. The age-related changes may be made worse by obesity, renal failure or the ingestion of certain drugs, or may be lessened by increased physical activity.
摘要
高血糖、糖耐量受损和非胰岛素依赖型糖尿病随着年龄的增长变得越来越普遍。其机制是在受体后水平对胰岛素作用不敏感。胰岛素分泌不足以及肝脏对胰岛素抑制葡萄糖输出作用的敏感性降低也会出现。与年龄相关的这些变化可能因肥胖、肾衰竭或某些药物的摄入而加重，或者因体力活动增加而减轻。
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