Riboldi P, Asero R, Marazzini L, Longhini E, Cherubini P, Pacetti M, Invernizzi F
Respiration. 1984;45(1):45-9. doi: 10.1159/000194596.
In order to confirm the usefulness of free plasma DNA detection in the diagnosis of pulmonary embolism (PE), we have studied 16 patients with PE, 33 with various diseases, and 13 normal subjects. Free plasma DNA was detectable in 15 of 16 patients with PE (94%) and in 3 control patients, but never in plasma from normal subjects. In most cases, DNA was detectable until the 10th day after PE. In conclusion, counterimmunoelectrophoresis is a rapid, inexpensive and specific test which may be used as an exclusion test in the detection of patients suspected of having PE, who will have to undergo more extensive evaluation.
为了证实游离血浆DNA检测在肺栓塞（PE）诊断中的实用性，我们研究了16例PE患者、33例患有各种疾病的患者以及13名正常受试者。16例PE患者中有15例（94%）可检测到游离血浆DNA，3例对照患者也可检测到，但正常受试者的血浆中从未检测到。在大多数情况下，直到PE发生后第10天仍可检测到DNA。总之，对流免疫电泳是一种快速、廉价且特异的检测方法，可作为疑似PE患者检测的排除试验，这些患者将需要进行更广泛的评估。
