Barada F A, Suratt P M, Davis J S, Sipes J N, Castle C A, Taylor R P, Godfrey S M
South Med J. 1980 Mar;73(3):345-6, 350. doi: 10.1097/00007611-198003000-00021.
Plasma samples from 46 patients with suspected pulmonary embolism and 25 patients with suspected acute myocardial infarction were analyzed for DNA by counterimmunoelectrophoresis (CIE). Anti-DNA serum was obtained from a patient with systemic lupus erythematosus who had a high titer of anti-DNA antibodies. Seven of eight patients (88%) with high probability of pulmonary embolism by lung scan criteria had free DNA in their plasma. Six of 21 patients (29%) with low probability scans for pulmonary embolism also had DNA in their plasma. None of the eight patients with normal scans and only one of 13 patients with myocardial infarction had DNA in their plasma. Detection of plasma DNA by CIE is a rapid and simple method of screening for pulmonary embolism.
采用对流免疫电泳（CIE）对46例疑似肺栓塞患者和25例疑似急性心肌梗死患者的血浆样本进行DNA分析。抗DNA血清取自一名系统性红斑狼疮患者，该患者抗DNA抗体效价较高。根据肺部扫描标准，8例高度疑似肺栓塞患者中有7例（88%）血浆中存在游离DNA。21例肺部扫描低疑似度患者中有6例（29%）血浆中也存在DNA。8例扫描正常的患者以及13例心肌梗死患者中只有1例血浆中存在DNA。通过CIE检测血浆DNA是一种快速简便的肺栓塞筛查方法。
