一项关于血浆DNA在肺栓塞诊断中的前瞻性研究。

A prospective study of plasma DNA in the diagnosis of pulmonary embolism.

作者信息

Sipes J N, Suratt P M, Teates C D, Barada F A, Davis J S, Tegtmeyer C J

出版信息

Am Rev Respir Dis. 1978 Sep;118(3):475-8. doi: 10.1164/arrd.1978.118.3.475.

DOI:10.1164/arrd.1978.118.3.475

Abstract

To assess the usefulness of plasma deoxyribonucleic acid (DNA) detection in the diagnosis of pulmonary embolism (PE), we prospectively studied the frequency and duration of the occurrence of free plasma DNA in 23 patients with PE and in 49 patients with pneumonia, myocardial infarction, thrombophlebitis, or normal lung scans. Plasma DNA was detected in 19 of the 23 patients (83 per cent) with PE and in none of the 49 patients with other diagnoses. Eighteen of the 19 PE patients with free DNA had persistence of DNA on all subsequent sampling for up to 5 days. In this series, plasma DNA had a sensitivity of 83 per cent in the diagnosis of PE and was extremely specific for PE. Thus, detection of free plasma DNA may be useful as a rapid, noninvasive test to aid in the diagnois of PE.

摘要

为评估血浆脱氧核糖核酸（DNA）检测在肺栓塞（PE）诊断中的实用性，我们前瞻性地研究了23例PE患者以及49例患有肺炎、心肌梗死、血栓性静脉炎或肺部扫描正常的患者中游离血浆DNA出现的频率和持续时间。23例PE患者中有19例（83%）检测到血浆DNA，而49例其他诊断患者中均未检测到。19例有游离DNA的PE患者中，有18例在随后所有样本检测中均持续检测到DNA，长达5天。在本系列研究中，血浆DNA诊断PE的敏感性为83%，且对PE具有极高的特异性。因此，检测游离血浆DNA可能作为一种快速、非侵入性的检测方法，有助于PE的诊断。