Tomasson H O, Brennan M, Bass M J
Can Med Assoc J. 1984 Feb 1;130(3):275-8.
In 1980 and 1982 two case reports documented reactivation of pulmonary tuberculosis in patients who had used nonsteroidal anti-inflammatory drugs (NSAIDs). A case-control study was designed to test the hypothesis that such an association does exist. Data for 38 patients were obtained from the patients' family physicians, and each patient was matched with a control from the same practice for age, sex, race and length of time in that practice. A statistically significant relation was found between the reactivation of tuberculosis and the use of NSAIDs. However, further research is imperative to determine whether the association is direct, indirect or secondary to an unknown factor. Physicians should keep in mind that NSAIDs are potent anti-inflammatory agents and may thus activate, spread and mask infections.
1980年和1982年有两份病例报告记录了使用非甾体抗炎药（NSAIDs）的患者发生肺结核复发的情况。一项病例对照研究旨在检验是否确实存在这种关联的假设。从患者的家庭医生处获取了38名患者的数据，并且为每位患者匹配了同一家诊所的一名年龄、性别、种族和在该诊所就诊时间均相同的对照。研究发现结核病复发与使用NSAIDs之间存在统计学上的显著关联。然而，必须进行进一步研究以确定这种关联是直接的、间接的还是由某个未知因素导致的继发性关联。医生应牢记NSAIDs是强效抗炎药，因此可能会激活、传播并掩盖感染。
